Trachyonychia in juvenile dermatomyositis: nail as a mirror to disease activity
نویسندگان
چکیده
منابع مشابه
Modelling disease activity in juvenile dermatomyositis: A Bayesian approach.
Juvenile dermatomyositis is the most common form of the juvenile idiopathic inflammatory myopathies characterised by muscle and skin inflammation, leading to symmetric proximal muscle weakness and cutaneous symptoms. It has a fluctuating course and varying prognosis. In a Bayesian framework, we develop a joint model for four longitudinal outcomes, which accounts for within individual variabilit...
متن کاملMyeloid cells which secrete S100 proteins in juvenile dermatomyositis may contribute to disease activity
Background Juvenile dermatomyositis (JDM) is thought to involve an autoimmune myositis, yet the elements of the immune response which damage muscle tissue in JDM remain unclear. Muscle tissue from early JDM shows infiltration by predominantly macrophage/myeloid cells. Traditional histopathology would suggest that these cells have a scavenger or 'repair' function; our data suggest otherwise. We ...
متن کاملJuvenile Dermatomyositis: A Review
Juvenile dermatomyositis is a systemic vasculopathy, affecting mainly the skin and muscle. In the United States, it is seen in more than three per million children per year. It is diagnosed on the basis of the criteria set by Bohan and Peter. The following review describes the characteristic clinical manifestations, the pathophysiology and immunology of the disease. The various treatment modali...
متن کاملJuvenile dermatomyositis.
Juvenile dermatomyositis (JDMS) is a chronic inflammatory condition characterized by muscle weakness and a distinctive rash caused by underlying vasculopathy. Long-term complications include subcutaneous and muscular calcification, contractures and in some cases the gradual development of a second connective tissue disease. Early aggressive treatment with systemic immunosuppressants and other a...
متن کاملJuvenile dermatomyositis.
The clinical profile of 7 children and their follow-up is described. There was female preponderance with mate to female ratio of 1:6. The median age of onset was 6 years. All the patients had skin rash, muscle weakness and abnormal enzyme profile. Muscle biopsy was performed in 6 and was abnormal in all of them. The electromyogram (EMG) was performed in 6 and was found abnormal in five. All the...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2016
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kew330